
All products in the kaplanMD | for transitioning skin collection contain the powerful Phytogenic Triactive Complex of Soy, Black Cohosh and Grapeseed Extract. Clinically proven to mimic the positive effects of estrogen, this Triactive is encapsulated in a patented microsphere time-release delivery system that penetrates the skin for greater efficacy.
Dr. Stuart Kaplan Answers Some Frequently Asked Questions:
- How Does the Phytogenic Triactive Complex Mimic the Positive Effects of Estrogen?
- How Does the Microsphere Time-release Delivery System Penetrate Skin?
- How Does Soy Work as a Phytoestrogen?
- How Does Black Cohosh Work as a Phytoestrogen?
- What are the Benefits of Grapeseed Extract?
- What are Antioxidants, and What Do they Do?
How Does the Phytogenic Triactive Complex Mimic the Positive Effects of Estrogen?
The Phytogenic Triactive Complex is the result of many years of researching phytoestrogens, or plant-derived substances, that have estrogen-like properties. Studies have shown that when estrogen levels are low for women, such as during perimenopause and menopause, phytoestrogens can mimic the effects of estrogen on the skin, without the side effects of synthetic estrogen.
The most potent phytoestrogens on the skin have proven to be Soy, Black Cohosh and Grapeseed Extract. Collectively, these three powerful ingredients make up the kaplanMD Phytogenic Triactive Complex. Encapsulated in a patented microsphere time-release delivery system, this restorative formula actually penetrates deep within the skin for maximum effectiveness.
How Does the Microsphere Time-release Delivery System Penetrate Skin?
Your skin is intelligently designed as a barrier to the external environment. Because our skin is so good at keeping things out, most skincare products never penetrate the skin, and stay only on your skin’s surface. Since your skin constantly sheds and regenerates, these products never have any long-term benefit — no matter how effective the ingredients are. Skincare products only work if they can penetrate your skin.
This is why all kaplanMD skincare solutions contain the microsphere time-release delivery system. Previously only available in prescription medications, the exclusive, patented microsphere technology delivers the kaplanMD Phytogenic Triactive Complex and other essential anti-aging and environmental protection ingredients deep within the skin. How is this done? As kaplanMD skincare solutions are applied to your skin, the rubbing motion activates enzymes in "programmed" marine collagen microspheres that release each formula over time as they penetrates deep into your skin. This means every ingredient in the kaplanMD skincare line is delivered exactly where you need it most, and delivered slowly so the benefits are maintained throughout the day.
How Does Soy Work as a Phytoestrogen?
Numerous clinical studies have shown that estrogen helps to preserve the skin's collagen content and its elastic properties, while aiding the maintenance of skin thickness. Soy, a natural selective estrogen receptor modulator (or phytoestrogen), mimics the effects of estrogen to counteract the negative effects of estrogen loss on the skin. Studies show that Soy, at a 3 percent concentration applied topically, increases the skin’s thickness up to 7 percent in two months, and 11.2 percent in three months. Soy has also been proven to improve skin hydration, smoothness and firmness. All kaplanMD "stay on" skincare solutions, including our Day Cream SPF 15 and Replenishing Night Cream, as well as the soon-to-be-released Perfecting Serum and Intensive Eye Cream, contain a 3 percent concentration of Soy for maximum effectiveness.
How Does Black Cohosh Work as a Phytoestrogen?
Black Cohosh is an herb originally used by Native Americans to ease painful menstruation. When taken orally, it is said be effective against hot flashes, and helpful when easing menstrual cramps and lightening the menstrual flow.
In terms of skin care, research has shown that Black Cohosh, when applied topically in the correct concentration, has been found to have a hormone-like structure, giving it an affinity to bind to human estrogen receptors. This quality enables Black Cohosh to help correct the negative effects of diminishing hormones on the skin. At the same time, Black Cohosh fights symptoms associated with photo-induced aging by preventing the breakdown of the skin’s structural support, increasing the synthesis of collagen and promoting skin-hydrating glycosaminoglycans, such as hyaluronic acid.
What are the Benefits of Grapeseed Extract?
Grapeseed Extract is a natural plant substance that has a concentrated source of antioxidants, such as polyphenols and oligomeric proanthocyanidins (OPC). Studies have shown OPC to be a powerful antioxidant 20 times more powerful than vitamin C, and 50 times more powerful than vitamin E. kaplanMD | for transitioning skin uses only the most advanced, patented topical blend of Grapeseed Extract and other natural antioxidants in its skincare solutions.
What are Antioxidants, and What Do They Do?
All living organisms have a natural supply of lipid-soluble antioxidants, such as Vitamin E and Carotenoids, and water-soluble antioxidants, such as Vitamin C and Enzymes, to protect against oxidative free-radicals. Free-radicals, which are created by air pollution and UV light, attack fatty acids and other components of cell membranes when in contact with the skin. The result is premature skin aging. Antioxidants capture free-radicals, thereby protecting your skin from harmful damage.
kaplanMD | for transitioning skin uses a topical Grapeseed Extract preparation, called CRODOSOME GSP-T. This synergistic blend of natural antioxidants combines both water and oil soluble antioxidants to protect skin from damaging free-radicals.

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